About the Wnt Community
The homepage is managed by Roel Nusse of Stanford University.
The website has comprehensive links and information on Wnt signalling: reviews, books, and a Linked-In site of forums and discussion, as well as notifications of Wnt meetings. Past meetings are listed on the history page.
The Wnt story
Wnt proteins form a family of highly conserved secreted signaling molecules that regulate cell-to-cell interactions during embryogenesis. Insights into the mechanisms of Wnt action have emerged from several systems: genetics in Drosophila and Caenorhabditis elegans; biochemistry in cell culture and ectopic gene expression in Xenopus embryos. Mutations in Wnt genes or Wnt pathway components lead to specific developmental defects, while various human diseases, including cancer, are caused by abnormal Wnt signaling. As currently understood, Wnt proteins bind to receptors of the Frizzled and LRP families on the cell surface. Through several cytoplasmic relay components, the signal is transduced to beta-catenin, which enters the nucleus and forms a complex with TCF to activate transcription of Wnt target genes (see diagrams of the Wnt pathway). In addition, several beta-catenin independent Wnt pathways have been described that govern processes like cell polarity, migration and co-ordinated tissue movement. Each branch of Wnt signalling has been linked to cancer.
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